certificate of analysis available on request Research Applications Suitable Laboratory Uses for 5-Amino-1MQ NNMT enzyme inhibition assays IC50 determination, target engagement confirmation, and 1-MNA quantification NAD+ salvage pathway modulation studies nicotinamide flux, NMN and NAD+ pool measurement SAM/SAH methyl-donor pathway and epigenetic methylation capacity research Adipocyte biology lipogenesis, adipocyte differentiation, fat mass, and lipid storage pathway studies SIRT1 and SIRT3 activation and insulin sensitivity pathway investigations Mitochondrial function and energy expenditure pathway research Skeletal muscle physiology muscle function, sarcopenia pathway, and mitophagy-related studies NNMT-overexpressing cancer cell line studies anti-proliferative and apoptotic pathway research Gut microbiome modulation research in diet-induced obesity models Cardiovascular metabolic pathway studies homocysteine, NF-B, STAT3, redox signalling Comparative NNMT inhibitor research 5-Amino-1MQ vs
TNBC cells can express high levels of the xCT cystine/glutamate antiporter, which leads to a reduction in xCT-associated glutathione levels, thus reducing cell viability and sensitizing the cells to ferroptosis (13)
Kamlin COF, T MJ, J LH, N SA
The expert should be able to make a plan that is specific for each patient while also providing all relevant material needed to make the right choice in regard to this procedure
