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Proteomics 8, 17441749 (2008)

The immunosuppressive properties of the tumor microenvironment (TME) further limit its efficacy: regulatory T cells (Tregs) suppress ferroptosis by consuming cysteine and secreting IL-10, while tumor cells escape through the Nrf2 pathway by upregulating GPX4 and FSP1

These mechanisms improve glycemic control in type 2 diabetes and contribute to weight loss by prolonging satiety and reducing appetite