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In order to adjust for confounders, the following covariate variables were selected as the independent variable: age, race, ethnicity, sex, BMI, history of chronic kidney disease (CKD), history of congestive heart failure (CHF), history of diabetes, history of gastric surgery, history of gastroparesis, whether bowel prep was used (e.g., underwent same day EGD-flexible sigmoidoscopy or EGD-colonoscopy), history of GLP-1RA use, and other medications known to contribute to delayed gastric emptying

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Yes, but theres no pharmacological rationale for combining them both activate overlapping melanocortin receptors (MC3R and MC4R), so co-administration simply increases the total agonist exposure without adding mechanistic diversity