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Therefore, the aim of the present study was to assess the effect of L-carnitine on Doxorubicin and Cyclophosphamide induced chemobrain in rats in addition to study the possible oxidative stress, inflammatory response, synaptic plasticity, liver-brain and kidney-brain related mechanisms

Conversely, at the protective level, low-dose/acute exposure mitigates inflammation via TNF signaling inhibition, activates the Nrf2 pathway to induce antioxidant enzymes (e.g., HO-1, NQO1) for oxidative stress resistance, and induces metabolic reprogramming (e.g., shifting from fatty acid oxidation to glucose oxidation under hypoxia) to maintain energy homeostasis

Neurochem Int