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Are there biomarker changes consistent with GLP-1 activation

Exendin-4 inhibits matrix metalloproteinase-9 activation and reduces infarct growth after focal cerebral ischemia in hyperglycemic mice

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Tesamorelin gained FDA approval in 2010 specifically for reducing visceral adipose tissue in HIV-associated lipodystrophy, with clinical trials showing 1518% reductions in visceral fat after 26 weeks at 2mg daily dosing