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At the pancreas, simultaneous GIPR and GLP-1R activation produces greater insulin secretion than either pathway alone

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It is required for healthy red blood cell production, maintenance of the myelin sheath, synthesis of DNA, and metabolism of homocysteine

Current evidence suggests intranasal delivery achieves significantly lower systemic bioavailability than injection, typically 2-5% without enhancement and potentially 15-45% with optimized formulations