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L-carnitine deficiency severely impairs the mitochondrial import of long-chain acyl-CoAs, directly limiting the acetyl-CoA pool required for ketogenesis (3)

Eur Respir J 48(1):205215 Svingen GF, Zuo H, Ueland PM, Seifert R, Lland KH, Pedersen ER, Schuster PM, Karlsson T, Tell GS, Schartum-Hansen H, Olset H (2018) Increased plasma trimethylamine-N-oxide is associated with incident atrial fibrillation

All ICD-10-CM codes reflect FY2026 NCHS/CMS tabular list (effective October 1, 2025)

If it holds up in larger, biopsy-confirmed studies, hepatic steatosis could become one of the areas where triple agonism has the strongest differentiated rationale though, as with everything about this molecule, that remains to be confirmed in the full program