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These studies revealed the beneficial effects of AOX supplementation in men with (a) abnormal semen quality, (b) varicocele, and (c) idiopathic or unexplained infertility (66)

Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]

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1 This landmark study builds on more than 20 years of research in obesity, a serious chronic disease associated with severe co-morbidities and outcomes