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This artifact is especially common in rats that are not exsanguinated at necropsy and the cytoplasmic vacuoles represent plasma influx into to affected cells (Figure 33 )

Unlike GHRP-6 and hexarelin, which increase cortisol, prolactin, and appetite alongside GH release, ipamorelin is reported to produce GH release with minimal off-target hormonal effects, which is why it has become a preferred pharmacological tool for isolating GH-axis effects from cortisol and prolactin-related confounders in experimental design

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A common feature of these two parasites is that, unlike other hematozoa (such as related Babesia ), they undergo a huge expansion within nucleated cells termed schizogony prior to their red blood cell stage