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The most common cause of diarrhea is a viral infection in the gut, often referred to as "intestinal flu" or "stomach flu." Other causes include: Food allergies Intestinal diseases (e.g., Crohn's disease, ulcerative colitis) Bacterial infections (e.g., food poisoning) Parasitic infections Reactions to medications (e.g., antibiotics, cancer drugs) Overactive thyroid (hyperthyroidism) In some cases, diarrhea may follow constipation, particularly in people with irritable bowel syndrome (IBS)