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Meanwhile, -syn can also be transported into mitochondria via VDAC, interfering with mitochondrial respiration (137)

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Keloid Senescent Fibroblast Elimination & SASP Suppression (Communications Biology, 2025) FOXO4-DRI Induces p53-pS15 Nuclear Exclusion and Apoptosis in Keloid Fibroblast Models A study published in Communications Biology (Nature Publishing Group, 2025) used single-cell RNA sequencing to characterise the senescent cell landscape in keloids pathological scars with tumour-like aggressiveness

Together with dietary antioxidants such as Vitamin C, Vitamin E, melatonin, and carotenoids [63, 64], these antioxidant systems serve as free radical scavengers by preventing, buffering, and repairing damages caused by OS, and enhancing the immune defense against degenerative diseases [65] (Fig