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Eligibility criteria include: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 3034.9 kg/m in certain high-risk groups Ethnicity-adjusted BMI thresholds apply: for people from Black African, African-Caribbean, South Asian, Chinese, or other Asian backgrounds, thresholds are reduced by 2

This would be a different product from orforglipron, essentially the same dual-receptor molecule but in pill form

By acting as a physiological repressor of NRF2 target genes at the ARE-binding site, knockdown or nuclear exclusion of BACH1 holds promising potential for reactivating the downregulated activity of NRF2 associated with disease

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