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Its broad transporter interaction profile has made it a valuable research tool for investigating DAT, NET, and SERT pharmacology, transporter-ligand binding dynamics, and the molecular mechanisms governing monoamine transporter function

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Regions with high flexibility, such as the S2 domain and -loop, stand out even more when all heavy atoms of the residue are considered

Although MYCN downregulation or overexpression are in the region of 50% or more, they are still within the natural range of variation observed in MNA and MYCN non-amplified cells, respectively ( Figure 4 To further measure cell death upon treatment with MitoQ, DPI and vincristine, we measured caspase 3/7 activation using Caspase-Glo 3/7 (Promega) ( Figure 4D )