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The second pathway uses betaine as a methyl donor, catalyzed by betaine homocysteine methyltransferase (BHMT)

221 Although the effects of vitamin D supplementation on the course of CKD are still unknown, it may play a role in mitigating certain CKD complications

In some embodiments, from about 10 mM to about 200 mM concentration of a buffer is present in the gel formulation