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Firstly, the spontaneous reporting system is affected by limitations within the FAERS database, including duplicate reports, reporting accuracy and quality, incomplete or insufficient details regarding drug administration (such as site, route, dose and timing), and the lack of important patient characteristics (such as medical history and comorbidities)

Data from a study showed that 4-HNE/protein adduct levels were higher in OA osteoblasts than in normal osteoblasts and when OA osteoblasts were treated with hydrogen peroxide [93]

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