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In a Phase 1 trial in healthy volunteers, intranasal doses of 1020 mg PT-141 significantly increased erectile rigidity time (rigid erections lasting on average ~24 minutes at the 20 mg dose, versus essentially none in the placebo group)

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After invasion into the host, mycobacteria induce NADPH oxidase 2 (NOX2) expression to generate superoxide radicals (O 2 ), which are then converted to more toxic hydrogen peroxide (H 2 O 2 ) by superoxide dismutase (SOD) and subsequently reduced to water and molecular oxygen by catalase [57, 58]