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This type of deficiency is called Pernicious Anemia

Furthermore, data from randomized clinical trials and meta-analysis indicate that vitamin B 12 in the forms of methylcobalamin and cyanocobalamin may increase serum vitamin B 12 levels, and resulted in decreased serum methylmalonic acid and homocysteine concentrations, and decreased pain intensity, memory loss, and impaired concentration

Preclinical Research Summary Preclinical research references discuss 5 Amino-1MQrelated observations derived from controlled experimental model systems used to examine nicotinamide N-methyltransferase (NNMT)associated metabolic and methylation pathways

Investigational interest includes relationships to oxidative metabolism , sirtuin-linked pathways, and age-related bioenergetic decline