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2019: PT-141 received FDA approval (as bremelanotide) for hypoactive sexual desire disorder (HSDD) in premenopausal women, following successful RECONNECT Phase III trials (Kingsberg et al., 2019)

A large retrospective cohort study from Weill Cornell Medical College - examining 255 patients (92% women, mean age 64) with DXA scans before and after starting semaglutide or tirzepatide - found that GLP-1 receptor agonist use was associated with greater annualized total hip bone loss in patients without diabetes, while patients with diabetes showed bone loss more comparable to non-users