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A serious problem in current clinical practice is that depressed patients are usually accompanied by other types of psychiatric disorders [6, 7], which inevitably increases the risk of developing major depressive disorder and emphasizes the importance of timely and effective control of the disorder [8]

Additionally, proteomics approaches, along with transcriptomics and metabolomics, have significant possibilities in this research area 171

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Furthermore, specific terms relating to adrenal gland function, such as glucocorticoids, mineralocorticoids, androgens, and adrenal hormone disorders such as adrenal insufficiency, Cushings syndrome, and adrenal tumors, were added to collect relevant literature