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IFIH1 encodes melanoma differentiation-associated protein 5 (MDA5), a ubiquitously expressed cytoplasmic RNA helicase and sensor that is crucial to survival after systemic viral infection by inducing an MAVS-mediated type I IFN immune response ( GWAS studies have linked at least four SNPs within IFIH1 to T1D risk and protection ( IFIH1 gene expression, resulting in a complete loss of dsRNA binding activity ( Ifih1 deficiency used NOD mice with an Ifih1 helicase 1 domain deletion or a premature stop codon, resulting in a functional gene knockout

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