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Protective effects and mechanisms of action of bioactive phytochemicals Numerous in vivo, in vitro, and ex vivo studies have shown that bioactive polyphenols possess a broad spectrum of therapeutic effects, such as immunomodulatory, antimicrobial, antioxidant, antimutagenic, hypolipidemic, hypoglycemic, gastroprotective, anti-inflammatory, anticancer, and chemopreventive properties[88]

The broader picture is that the next generation of obesity treatments involves multi-target approaches, whether through single molecules activating multiple receptors (tirzepatide, retatrutide, survodutide, mazdutide) or through combination therapies pairing separate compounds (CagriSema)

HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P25/00Drugs for disorders of the nervous system AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE

Pre-emptive short-term nicotinamide mononucleotide treatment in a mouse model of diabetic nephropathy