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2.3.1 NF-B NF-B can participate in the occurrence and development of pathological cardiac remodeling by regulating the synthesis and release of ECM, cytokines, and chemokines (Wei et al., 2013

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The peptides very short half-life (3 minutes) means it does not accumulate in tissues over time, reducing concerns about long-term bioaccumulation

It is also why elevated IGF-1 raises theoretical concerns about cancer promotion in individuals with pre-existing malignancy or strong genetic risk.8 Any peptide protocol in an adult over 60 must include a pre-treatment cancer screen and should not be initiated in individuals with active or recent cancer history without oncology input