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It is a analog of human IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arginine (Arg or R) for the Glutamic Acid (Glu or E) at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus
Ann Rheum Dis 74(1):303310 Fuggle N, Curtis E, Shaw S, Spooner L, Bruyre O, Ntani G et al (2019) Safety of opioids in osteoarthritis: outcomes of a systematic review and meta-analysis
Arginine is a precursor for the synthesis of proteins, urea, and various signaling molecules [122]
Study procedure During the study, the appropriate temperature was maintained between 20-24 C, with relative humidity of 40-70% and fluorescent lighting for 12 hours a day
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