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ectopic fat deposition in the liver and epicardium triggers inflammation, disrupts myocardial energy metabolism, and promotes fibrosis, contributing to cardiac dysfunction and diastolic impairment

Upon receptor binding, it initiates Gq-coupled intracellular signaling, thus activating phospholipase C, generating inositol trisphosphate, and mobilizing intracellular calcium

GLP-1 achieves the decrease in blood glucose levels by potentiating glucose-induced insulin secretion (the incretin-effect), improving insulin sensitivity and inhibiting glucagon release

More rarely, these medications may lead to more serious conditions like pancreatitis