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The -cyperone (-CYP) intervention significantly inhibits the abnormal upregulation of HDAC2 expression and reduces the changes including the necrosis, degeneration of renal tubules, interstitial fibrosis, and neutrophil infiltration in the STZ-induced diabetic rat model with I/R treatment and HG-treated NRK-52E cells

The same analysis was done in N2a cells co-expressing the phosphatidylserine biosensor mRFP-Lact-C2 25 and the different GFP-fusions, transfected at equal plasmid ratio

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They have an injury secondary to inflammation or something like that