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The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists

The structures reveal a common binding pocket for negative allosteric modulators, present in both GLP-1R and GCGR 3 and located outside helices VVII near the intracellular half of the receptor

Its responsible for more than 56,000 emergency room visits and an estimated 458 deaths every year due to acute liver failure