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Tissue microarray (TMA) analysis demonstrated that PDHA1 was significantly overexpressed in cancerous tissues compared to adjacent normal tissues, with higher PDHA1 expression correlating with worse overall survival (OS), disease-free survival (DFS), and advanced Gleason scores (Fig

Many drugs were only effective at 100 M and were were deprioritized due to their limited potency

RB, MS, SD, ZS, KJ, and RD: data curation

GLP-1RAs mimic the incretin hormone GLP-1 to enhance glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and reduce appetite through central nervous system pathways [21,22]