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Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases

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Screening efficacy is measured by the reduction of cervical cancer occurrence and mortality achieved after screening [149]

Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]