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Glutathione deficiency in older adults appears to stem from impaired synthesis, driven both by reduced availability of precursor amino acids (cysteine and glycine) and, per more recent research, by lower expression of the enzymes needed to produce glutathione

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Genistein has a higher binding affinity for ER than ER and its activity depends on endogenous estrogen levels and ER expression (Irrera et al., 2017

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