Systemic effects that have been reported in trials, or that are mechanistically expected from elevated GH and IGF-1, include: Water retention and mild edema , particularly in the hands, ankles, and face Tingling, numbness, or 'pins and needles' (paresthesia) , sometimes linked to fluid pressure on nerves Headache and facial flushing , often shortly after administration Joint aches or stiffness (arthralgia) Transient changes in blood glucose due to GH's counter-regulatory effect on insulin Fatigue, dizziness, or a feeling of light-headedness in some individuals It is important to be candid about the limits of this evidence
Fishman EK, Soyer P, Bliss DF, Bluemke DA, Devine N
When cost efficiency is a priority, precursor-based strategies such as NAC + glycine may achieve similar biological outcomes while maintaining competitive retail pricing
Procedure : Initially an experiment was performed that demonstrated the presence of glutathione in the liver cytosol fraction