however, these drugs have been misused Currently available data do not suggest that rhGH treatment should be used to promote longevity Lack of GH action in mouse models is associated with extended longevity, but the mechanism underlying the increased lifespan has yet to be established Given the effects of reduced GH/IGF-1 signalling on lifespan in rodents, decreased GH action might be beneficial for humans, but clinical trials are needed to assess long-term outcome of GH/IGF-1 inhibition This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 189,00 per year only 15,75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF
As more data emerges, the complete safety profile will become clearer
Journal International De Vitaminologie Et De Nutrition , 75 (1), 3-9
Se-containing molecules can affect gene expression, cell signaling pathways, DNA repair/damage, and angiogenesis and metastasis through the formation of ROS and the oxidation of protein thiol groups [315]
