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Patients recovered from COVID-19 show increased risk and about 1-year burden of GI disorders such as irregular bowel movement, acid-related illnesses (i.e., dyspepsia, gastroesophageal reflux condition, peptic ulcers), acute pancreatitis, hepatic and biliary dysfunction 202

Hyperglycemia-induced pathways leading to DN Activation of the Polyol Pathway: Aldose reductase transforms excess glucose into sorbitol, leading to an imbalance in cell osmotic and lowering antioxidant levels

Compounded medications are prepared for an individual patient and are not FDA-approved

High Met diet causes alteration of hepatic prooxidant/antioxidant status and oxidative stress parameters in rats ( Met is directly converted by MATI/MATIII into SAMe, and MATI/MATIII deficiency could lead to decreased SAMe levels and its downstream products including GSH