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[94] [95] Tadalafil, a phosphodiesterase-5 inhibitor, was considered then rejected by NICE in the UK for the treatment of symptoms associated with BPH

Firstly, resveratrol decreases the expression of genes that are responsible for encoding the drug-metabolizing enzymes and drug transporters like ABC efflux transporters and proteins like MRP1/ABCC1 that contribute to the elimination of cancer drugs and chemoresistance [220, 221]

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