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Indeed, during APAP-induced toxicity there is an increased generation of mitochondrial superoxide anion production, stimulated by impaired mitochondrial respiration and formation of adducts between the reactive metabolite NAPQI and sulfhydryls moieties from mitochondrial proteins (Yan et al., 2010)

[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Amaral E.P., Conceicao E.L., Costa D.L., Rocha M.S., Marinho J.M., Cordeiro-Santos M., D'Imperio-Lima M.R., Barbosa T., Sher A., Andrade B.B

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