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The decades-old stepwise approach to type 2 diabetes treatment can delay the use of effective modern therapies, allowing high blood sugar and related complications to progress

In this Review, we evaluate the translational evidence supporting GLP-1RAs as candidate disease-modifying therapies for NDDs, describe mechanistic pathways linking metabolic dysfunction to neuronal vulnerability, and outline remaining challenges and research priorities in this rapidly evolving field

Hypothalamic circuits regulating appetite and energy homeostasis: Pathways to obesity

doi: 10.1042/bst0160635 King, GF, Deegan, J, Smith, R, Matouschek, A and Campbell, ID (1988)