miRNAs are small (2023-nucleotides), endogenous, single-stranded noncoding RNAs that regulate gene expression by pairing to sequence-specific binding sites in mRNAs to direct post-transcriptional repression and consequent inhibition of protein translation or degradation of the mRNA targets [179,180,181]
Concerns about adverse effects, particularly the risk of dependence, and reports of tinnitus exacerbation upon discontinuation 115 indicate the need for caution, and future research could clarify whether specific patient subgroups might benefit from targeted, short-duration BZD therapy under strict clinical supervision
Its use is investigational across all indications listed below
These include lack of exercise, drinking alcohol, inadequate sleep, and an unhealthy diet