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Amino acids are the fundamental building blocks of proteins, and in this specific combination, they create a molecule that acts like a cellular bodyguard

Statements Author contributions EK: Writing review & editing, Writing original draft, Project administration, Funding acquisition, Formal analysis

Studies have demonstrated that the lifespan of mice with OC is considerably reduced owing to the continuous activity of N1ICD, which leads to the aging of endothelial cells, increased expression of chemokines and the adhesion molecule VCAM1, and facilitates recruitment of neutrophils and invasion of tumors (70,74)

These findings establish innate RNA sensing as an intrinsic driver of hematopoietic stem cell aging and highlight modulation of MDA5-dependent pathways as a potential strategy to mitigate age-related hematopoietic dysfunction