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Thus, we should consider whether patients with Child-Pugh B or C disease can tolerate the dose established in clinical trials because in the past, most clinical trials were conducted in patients with Child-Pugh A disease

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Indeed, these behavioral improvements are clear indicators of gut microbiota modulation in which Akkermansia may increase along with beneficial SCFAs such as acetate and propionate, and the decrease of isobutyrate and stable n-butyrate levels in the gut