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Written informed consent for participation was not required from the participants or the participants legal guardians/next of kin because data were obtained from administrative datasets encompassing primary, secondary, and tertiary care for Brazilian patients across all five geographic regions (North, Northeast, Central-West, South, and Southeast)

Intracellular roles of selenium metabolism and selenoproteins in cartilage Chondrogenic differentiation programs of progenitor cells Selenium exerts various beneficial effects to promote proliferation and differentiation of chondrogenic progenitor cells 110,111

The methodological quality of the included studies varied

13.9%) and cT1 (105.1% vs