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Collectively, the combined impairment of folding, degradation and chaperone systems amplifies neuronal vulnerability to ethanol-induced stressors and establishes disruption of protein homeostasis as a central axis of alcohol-related neurodegeneration

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These neuroprotective genes are important for detoxifying heavy metals (151)

In addition, riboflavin can stimulate flavin-based extracellular electron transfer (FLEET) by Lactobacillaceae , as recently learned from Lactiplantibacillus plantarum and vegetable fermentations 209