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Pro-inflammatory and proatherogenic mCRP, but not nCRP, induces ROS monocyte/macrophage production and facilitates macrophage uptake of necrotic cells (170, 192) contributing to foam cell formation, atherosclerotic plaque formation and plaque rupture or destabilization (190, 191)

The results are mixed: some musculoskeletal studies show enhanced local healing with proximal injection, while others show comparable efficacy between subcutaneous and peri-lesional routes