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The worldwide prevalence of NTDs is estimated to be 2 per 1,000 births, which translates to 214,000-322,000 cases annually (30)

Side effects may temporarily increase around a dose change, then settle as the body adapts

Our group has recently invented a molecular combination (cARLA) synergistically targeting signaling pathways related to BBB maturation that elevated the barrier tightness and other BBB-specific properties in several BBB culture models including human stem cell-based ones [40]

Semaglutides trade-offs are cost, gastrointestinal side effects, contraindications including medullary thyroid carcinoma history, and the need for careful titration