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The December 2024 release of Phase 3 TRIUMPH-4 trial results marked a watershed moment in obesity medicine: participants on the highest dose achieved an average weight loss of 28.7% over 68 weeksthe most substantial efficacy demonstrated in any obesity trial to date

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Tirzepatide is the most direct comparison, operating as a dual GIP/GLP-1 receptor agonist

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doi:10.1016/j.molmet.2019.09.010 Hallare J

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