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Synapse specificity of long-term potentiation breaks down at short distances

[13] The first reaction of the carnitine shuttle is a two-step process catalyzed by a family of isozymes of acyl-CoA synthetase that are found in the outer mitochondrial membrane , where they promote the activation of fatty acids by forming a thioester bond between the fatty acid carboxyl group and the thiol group of coenzyme A to yield a fatty acylCoA

In both theory and practice, given the beneficial effects obtained [11,29], the counteraction of free radical formation (along with any effect on NO-level or eNOS expression) and its beneficial effects in neurodegenerative diseases support each others effects

Cell 153 , 12661280 (2013)