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Although DSM-5 diagnosis is defined through multiple behavioral criteria encompassing impaired control, social dysfunction, continued use despite harm, and tolerance or withdrawal, converging clinical and preclinical evidence indicates that the core pathological feature of SUDs is the progressive loss of control over intake (O'Brien, 2005)

Based on the careful analysis of the outputs of several biophysical tools, these authors have made a set of very important conclusions: good agreement between the ultracentrifuge and Sephadex experiments was obtained on the assumption that Sephadex chromatography depends on the effective hydrodynamic radii of proteins and not on their molecular weights

Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study