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Considerations for specific populations Despite the adherence improvement and convenience of GLP-1 patches, they may not be the best option for some people, including: Elderly patients usually have frail skin, making it challenging to apply and remove the transdermal patch

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In mice, CHAC1/BOTCH promotes neuronal differentiation by inhibiting NOTCH1 and both its depletion and overproduction severely disrupt neurogenesis ( CHAC1/BOTCH in zebrafish leads to severe defects in brain, heart and myotome development, resulting in embryonic lethality, highlighting its conserved and essential role (Yadav et al., 2019)