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DMT1 is a key protein regulating iron balance, and DMT1 inhibitors have been reported to selectively target CSCs in primary cancer cells and circulating cancer cells, causing ferroptosis in breast cancer CSCs and reversing multidrug resistance through lysosomal iron accumulation and ROS production

No doubt the fact that surgical anesthetics were being widely used by this time had something to do with this

This modification is catalyzed by histone acetyltransferases (HATs) (also known as lysine acetyltransferases (KATs)) and reversed by histone deacetylases (HDACs)