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Their evidence base comes from trial programs such as STEP (semaglutide for weight management, published in The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

Neves JS, Packer M, Ferreira JP (2023) Increased risk of heart failure hospitalization with GLP-1 receptor agonists in patients with reduced ejection fraction: a meta-analysis of the EXSCEL and fight trials