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It was hypothesized during this investigation that these components might be "somatomedins," leading to the designation of these compounds as "insulin-like growth factors." (1) Further explorations into the insulin-like growth factors involved gene-targeting approaches to potentially enhance their bioavailability and potency

Ipamorelin is notable for its selectivity, unlike other GHS-R agonists, research indicates it produces minimal effects on ACTH, cortisol, or prolactin in research models (Raun et al., Endocrinology, 1998)

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