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AES (Supplementary Note 1) were synthesized by PCR amplification of the Kan R cassette of pKD4 using primers containing 50 bp identity arms (Supplementary Table 2)

- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

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